欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-Idelalisib
Idelalisib

Chemical Structure : Idelalisib

CAS No.: 870281-82-6

加入收藏

Idelalisib (CAL-101;GS-1101;GS1101;GS1101)

货号: PC-43336Not For Human Use, Lab Use Only.

Idelalisib (CAL-101, GS-1101) is a potent, selective inhibitor of PI3K p110δ with IC50 of 2.5 nM, 40- to 300-fold selectivity over other class I PI3Ks (p110α/βγ, IC50=820/565/89nM), and 400- to 4000-fold over C2β, hVPS34, DNA-PK, and mTOR.

规格 价格 库存 数量
50 mg ￥1280 In stock
100 mg ￥1880 In stock
200 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Idelalisib (CAL-101, GS-1101) is a potent, selective inhibitor of PI3K p110δ with IC50 of 2.5 nM, 40- to 300-fold selectivity over other class I PI3Ks (p110α/βγ, IC50=820/565/89nM), and 400- to 4000-fold over C2β, hVPS34, DNA-PK, and mTOR.
Idelalisib (CAL-101, GS-1101) blocks FcϵRI p110δ-mediated CD63 expression in basophils with an EC50 of 8 nM.
Idelalisib (CAL-101, GS-1101) blocks constitutive PI3K signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in PARP and caspase cleavage and an induction of apoptosis in multiple B-cell malignancies.

物理化学性质&存储条件

分子量 415.423
分子式 C22H18FN7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 59.7 mg/mL
Chemical Name/SMILES

4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-

参考文献

1. Hoellenriegel J, et al. Blood. 2011 Sep 29;118(13):3603-12.

2. Herman SE, et al. Blood. 2010 Sep 23;116(12):2078-88.

3. Lannutti BJ, et al. Blood. 2011 Jan 13;117(2):591-4.

4. Bodo J, et al. Br J Haematol. 2013 Oct;163(1):72-80.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: