Chemical Structure : Ibalizumab
CAS No.: 680188-33-4
货号: PC-Ab1096Not For Human Use, Lab Use Only.
Ibalizumab (TMB-355) is a humanized IgG4 monoclonal antibody, blocks the entry of human immunodeficiency virus type 1 (HIV-1) by noncompetitive binding to CD4 T cell receptors. Ibalizumab specifically leads to conformational changes of the CD4 T cell receptor-gp120 complex thus preventing HIV fusion and entry. Ibalizumab is classified as an entry inhibitor. However, its action mechanism differs from previously known HIV entry inhibitors such as enfuvirtide (a HIV fusion inhibitor) and maraviroc
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Ibalizumab (TMB-355) is a humanized IgG4 monoclonal antibody, blocks the entry of human immunodeficiency virus type 1 (HIV-1) by noncompetitive binding to CD4 T cell receptors. Ibalizumab specifically leads to conformational changes of the CD4 T cell receptor-gp120 complex thus preventing HIV fusion and entry. Ibalizumab is classified as an entry inhibitor. However, its action mechanism differs from previously known HIV entry inhibitors such as enfuvirtide (a HIV fusion inhibitor) and maraviroc (a CCR5 coreceptor antagonist).
分子量 | ||
分子式 | Human IgG4-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Ibalizumab; Trogarzo; TMB-355; TMB35; 680188-33-4; ibalizumab-uiyk; Anti-human T lymphocyte CD4; Anti-human CD4 glycoprotein. |
1. 1, Song R, et al. J Virol. 2010 Jul;84(14):6935-42. 2, Pace CS, et al. J Acquir Immune Defic Syndr. 2013 Jan 1;62(1):1-9. 3, Toma J, et al. J Virol. 2011 Apr;85(8):3872-80. 4, Bruno CJ, et al. J Antimicrob Chemother. 2010 Sep;65(9):1839-41.
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