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首页-抗体和重组蛋白-Biosimilar Antibody-Ibalizumab
Ibalizumab

Chemical Structure : Ibalizumab

CAS No.: 680188-33-4

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Ibalizumab (Anti-human CD4 mAb, human IgG4-Kappa; TMB-355)

货号: PC-Ab1096Not For Human Use, Lab Use Only.

Ibalizumab (TMB-355) is a humanized IgG4 monoclonal antibody, blocks the entry of human immunodeficiency virus type 1 (HIV-1) by noncompetitive binding to CD4 T cell receptors. Ibalizumab specifically leads to conformational changes of the CD4 T cell receptor-gp120 complex thus preventing HIV fusion and entry. Ibalizumab is classified as an entry inhibitor. However, its action mechanism differs from previously known HIV entry inhibitors such as enfuvirtide (a HIV fusion inhibitor) and maraviroc

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ibalizumab (TMB-355) is a humanized IgG4 monoclonal antibody, blocks the entry of human immunodeficiency virus type 1 (HIV-1) by noncompetitive binding to CD4 T cell receptors. Ibalizumab specifically leads to conformational changes of the CD4 T cell receptor-gp120 complex thus preventing HIV fusion and entry. Ibalizumab is classified as an entry inhibitor. However, its action mechanism differs from previously known HIV entry inhibitors such as enfuvirtide (a HIV fusion inhibitor) and maraviroc (a CCR5 coreceptor antagonist).

物理化学性质&存储条件

分子量
分子式 Human IgG4-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Ibalizumab; Trogarzo; TMB-355; TMB35; 680188-33-4; ibalizumab-uiyk; Anti-human T lymphocyte CD4; Anti-human CD4 glycoprotein.

参考文献

1. 1, Song R, et al. J Virol. 2010 Jul;84(14):6935-42.  2, Pace CS, et al. J Acquir Immune Defic Syndr. 2013 Jan 1;62(1):1-9.  3, Toma J, et al. J Virol. 2011 Apr;85(8):3872-80.  4, Bruno CJ, et al. J Antimicrob Chemother. 2010 Sep;65(9):1839-41.

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