IPPQ

Chemical Structure : IPPQ

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货号: PC-20121Not For Human Use, Lab Use Only.

IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain).

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain).
IPPQ inhibited CaV2.2 currents in sensory neurons.
IPPQ inhibited pre-synaptic localization of CaV2.2 in vivo.
IPPQ inhibited spinal neurotransmission, which resulted in decreased neurotransmitter release.
IPPQ exhibited anti-nociceptive effect in naïve rats and reversed mechanical allodynia and thermal hyperalgesia in rodent models of acute, neuropathic, and genetic pain.

物理化学性质&存储条件

分子量	429.52
分子式	C25H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-dimethylisoxazol-4-yl)-N-((4-((3-phenylpropyl)amino)quinazolin-2-yl)methyl)acetamide

参考文献

1. Dongzhi Ran, et al. Channels (Austin). 2021 Dec;15(1):128-135.

IPPQ

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物理化学性质&存储条件

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IPPQ

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