HO53 | HDAC3 inhibitor | Probechem Biochemicals

Chemical Structure : HO53

加入收藏

HO53 (HDAC3 inhibitor HO53, CAMP expression inducer)

货号: PC-20239Not For Human Use, Lab Use Only.

HO53 is a small moecule inducer of cathelicidin antimicrobial peptide gene (CAMP) expression in bronchial epithelium cells, HO53 is a histone deacetylase (HDAC) inhibitor, interacts directly with HDAC3.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HO53 is a small moecule inducer of cathelicidin antimicrobial peptide gene (CAMP) expression in bronchial epithelium cells, HO53 is a histone deacetylase (HDAC) inhibitor, interacts directly with HDAC3.
HO53 treatment affects expression of multiple genes and leads to Histone 3 acetylation on undifferentiated BCi cells.
HO53 induces CAMP gene expression through modulation of HAT/HDAC activity.
HO53 increases expressions of STAT3 and HIF1A, which are involved in CAMP expression in BCi cells.
HO53 treatment leads to changes in the expression of genes of the glycolysis and the TCA cycle.
HO53 induces a progressive change in the expression of important genes related to the metabolism in BCi cells (SLC2A4, GCKR, PFKP, ALDOB, PGAM2, PDK4, PDK2 and OGDHL).

物理化学性质&存储条件

分子量	410.43
分子式	C20H22N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-aminophenyl)-4-(2-((1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl)methoxy)acetamido)benzamide

参考文献

1. Barrier ML, et al. Mol Immunol. 2023 Mar;155:153-164.

HO53 (HDAC3 inhibitor HO53, CAMP expression inducer)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

HO53 (HDAC3 inhibitor HO53, CAMP expression inducer)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.