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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Arenavirus-HNC-1664
HNC-1664

Chemical Structure : HNC-1664

CAS No.: 2127358-36-3

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HNC-1664 (HNC1664)

货号: PC-23767Not For Human Use, Lab Use Only.

HNC-1664 is an adenosine analog with broad-spectrum antiviral activity against positive-strand coronaviruses and negative-strand arenaviruses, inhibits SARS-CoV-2 WT strain with IC50 of 29 nM, inhibits viral RdRP activity by competing with ATP in a non-catalytic manner.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HNC-1664 is an adenosine analog with broad-spectrum antiviral activity against positive-strand coronaviruses and negative-strand arenaviruses, inhibits SARS-CoV-2 WT strain with IC50 of 29 nM, inhibits viral RdRP activity by competing with ATP in a non-catalytic manner.
HNC-1664 robustly inhibitsSARS-CoV-2 replication in Caco-2 cells, with an IC50 value of 76 nM, and 90.28% reduction in the viral protein concentration at 10 μM, without significant cytotoxicity.
HNC-1664 robustly inhibits viral production, with IC50 values of 0.37 μM, 1.14 μM, and 0.12 μM, respectively, against ongoing SARS-CoV-2 variants of concern (VOCs) XBB.1.18.1, HK.3.1 and BF.7.14 variants in Vero E6 cell lines.
HNC-1664 exhibits high potency against these variants, with IC50 values of 0.019 μM, 0.064 μM, 0.084 μM and 0.096 μM, respectively, against prevalent emerging VOCs, including alpha, beta, delta and Omicron BA.1.
HNC-1664 reduces HCoV-229E and HCoV-OC43 replication in a dose-dependent manner.
HNC-1664 has potent broad-spectrum antiviral effects on different families of RNA viruses, including coronaviruses and arenaviruses.
HNC-1664 potently protected K18-hACE2 mice against lethal SARS-CoV-2 delta variant infection via in vivo antiviral efficacy and suppressed viral production and virus-induced pathological injury in tissues.
HNC-1664 inhibits SARS-CoV-2 and LASV RdRP activity by competing with ATP in a non-catalytic manner.

物理化学性质&存储条件

分子量 393.16
分子式 C12H13FIN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3R,4S,5R)-4-fluoro-2-(hydroxymethyl)-5-(5-iodo-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl) tetrahydrofuran-3-ol

参考文献

1. Jia X, et al. Nat Commun. 2024 Dec 30;15(1):10750.

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