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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-HBX-19818
HBX-19818

Chemical Structure : HBX-19818

CAS No.: 1426944-49-1

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HBX-19818 (HBX19818)

货号: PC-45339Not For Human Use, Lab Use Only.

HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.
HBX-19818 exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.
HBX-19818 reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.

物理化学性质&存储条件

分子量 421.96
分子式 C25H28ClN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO (Ultrasonic Needed)
Chemical Name/SMILES

2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-

参考文献

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.

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