Glufosfamide |CAS:132682-98-5 Probechem Biochemicals

Chemical Structure : Glufosfamide

CAS No.: 132682-98-5

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Glufosfamide (D-19575, D19575)

货号: PC-61486Not For Human Use, Lab Use Only.

A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.

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10 mg	￥4580	In stock
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生物&药学活性

Glufosfamide (D19575) is a conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.
Glufosfamide has the better cell permeability than ifosfamide.
Glufosfamide utilizes the normal cell glucose transport mechanism (SAAT1) for transport into the cell, enhances the activity of gemcitabine in vitro and in vivo.

物理化学性质&存储条件

分子量	383.16
分子式	C10H21Cl2N2O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-Bis(2-chloroethyl)phosphorodiamidic acid beta-D-glucopyranosyl ester

参考文献

1. Veyhl M, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2914-9.

2. Styczynski J, et al. Anticancer Res. 2002 Jan-Feb;22(1A):247-50.

3. Seker H, et al. Br J Cancer. 2000 Feb;82(3):629-34.

4. Ammons WS, et al. Neoplasia. 2007 Aug;9(8):625-33.

Glufosfamide (D-19575, D19575)

生物&药学活性

物理化学性质&存储条件

参考文献

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Glufosfamide (D-19575, D19575)

生物&药学活性

物理化学性质&存储条件

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