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首页-抗体和重组蛋白-Biosimilar Antibody-Gantenerumab
Gantenerumab

Chemical Structure : Gantenerumab

CAS No.: 1043556-46-2

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Gantenerumab (Anti-human amyloid β mAb, human IgG1-Kappa; RG1450)

货号: PC-Ab1093Not For Human Use, Lab Use Only.

Gantenerumab (RG1450, RO4909832) is a fully human IgG1 antibody designed to bind with subnanomolar affinity to a conformational epitope on Aβ fibrils. It encompasses both N-terminal and central amino acids of Aβ. The therapeutic rationale for this antibody is that it acts centrally to disassemble and degrade amyloid plaques by recruiting microglia and activating phagocytosis. bind and reduce amyloid-beta plaque formation in the brain, a hallmark of Alzheimer’s. It also neutralizes oligomeric Aβ4

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Gantenerumab (RG1450, RO4909832) is a fully human IgG1 antibody designed to bind with subnanomolar affinity to a conformational epitope on Aβ fibrils. It encompasses both N-terminal and central amino acids of Aβ. The therapeutic rationale for this antibody is that it acts centrally to disassemble and degrade amyloid plaques by recruiting microglia and activating phagocytosis. bind and reduce amyloid-beta plaque formation in the brain, a hallmark of Alzheimer’s. It also neutralizes oligomeric Aβ42-mediated inhibitory effects on long-term potentiation in rat brains. In APP/PS-1 transgenic mice, gantenerumab binds to cerebral Aβ, reduces small plaques by recruiting microglia, and prevents new plaque formation. Gantenerumab does not alter plasma Aβ.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Gantenerumab; RG1450; RO4909832; 1043556-46-2; Anti human Amyloid beta; Beta Amyloid; Amyloid-β; Anti human Aβ; Anti-human beta-amyloid

参考文献

1. 1, Bohrmann B, et al. J Alzheimers Dis. 2012;28(1):49-69. 2, Delrieu J, et al. Expert Opin Biol Ther. 2012 Aug;12(8):1077-86. 3, Novakovic D, et al. Drug Des Devel Ther. 2013 Nov 13;7:1359-64. 4, Jacobsen H, et al. J Neurosci. 2014 Aug 27;34(35):11621-30.

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