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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-GSK951A
GSK951A

Chemical Structure : GSK951A

CAS No.: 1403602-33-4

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GSK951A (GSK-951A)

货号: PC-61005Not For Human Use, Lab Use Only.

GSK951A is a small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM, targets enoyl-coenzyme A (CoA) hydratase EchA6 with binding Kd of 0.45 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GSK951A is a small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM, targets enoyl-coenzyme A (CoA) hydratase EchA6 with binding Kd of 0.45 uM.
    GSK951A suppresses mycolic acid synthesis and EchA6 is essential, and are bactericidal in mouse model of chronic tuberculosis infection.

    物理化学性质&存储条件

    分子量 472.468
    分子式 C24H23F3N4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

    参考文献

    1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.

    2. Remuiñán MJ, et al. PLoS One. 2013 Apr 17;8(4):e60933.

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