GSK-1842799 |CAS:1005407-76-0 Probechem Biochemicals

首页-小分子抑制剂&激动剂-GPCR-Lysophospholipid Receptor-GSK-1842799

Chemical Structure : GSK-1842799

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GSK-1842799 (GSK1842799 )

货号: PC-61604Not For Human Use, Lab Use Only.

GSK-1842799 is a potent, selective, oral bioavailable S1P1 agonist with bind affinity of 0.52 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK-1842799 is a potent, selective, oral bioavailable S1P1 agonist with bind affinity of 0.52 nM.
GSK-1842799 displays an excellent selectivity (>3,000-fold) for S1P1 over S1P3.
GSK-1842799 significantly reduces blood lymphocyte at 3 mg/kg, achieves efficacy equivalent to FTY720 in the mouse EAE model of MS.

物理化学性质&存储条件

分子量	431.518
分子式	C20H28F3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-2-(5-(4-(octyloxy)-3-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)propan-1-ol

参考文献

1. Deng H, et al. ACS Med Chem Lett. 2013 Aug 27;4(10):942-7.

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GSK-1842799 (GSK1842799 )

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK-1842799 (GSK1842799 )

生物&药学活性

物理化学性质&存储条件

参考文献

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