GBT601 (Osivelotor, GBT021601)

Chemical Structure : GBT601

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货号: PC-20064Not For Human Use, Lab Use Only.

GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs.

物理化学性质&存储条件

分子量	386.40
分子式	C20H22N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Hydroxy-6-[[(3S)-4-[[2-(2-hydroxyethyl)-3-pyridinyl]carbonyl]-3-morpholinyl]methoxy]benzaldehyde

参考文献

1. R. Clark Clark Brown, et al. Blood. Volume 138, Supplement 1, 23 November 2021, Page 3099