GB-83 |CAS:1252806-86-2 Probechem Biochemicals

Chemical Structure : GB-83

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GB-83 (PAR2 inhibitor GB83)

货号: PC-61618Not For Human Use, Lab Use Only.

GB-83 is a selective, reversible PAR2 (Protease-activated receptor 2) antagonist with IC50 of 2 uM.

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1 g		Get quote

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生物&药学活性

GB-83 is a selective, reversible PAR2 (Protease-activated receptor 2) antagonist with IC50 of 2 uM.
GB-83 prevents upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases in human atrial tissue.
GB-83 reverses neutrophil elastase-induced synovitis and pain in mice.

物理化学性质&存储条件

分子量	548.72
分子式	C32H44N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-3-cyclohexyl-1-((2S,3S)-1-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)-3-methyl-1-oxopentan-2-ylamino)-1-oxopropan-2-yl)isoxazole-5-carboxamide

参考文献

1. Barry GD, et al. J Med Chem. 2010 Oct 28;53(20):7428-40.

2. Bukowska A, et al. Eur J Pharmacol. 2013 Oct 15;718(1-3):114-23.

3. Muley MM, et al. Br J Pharmacol. 2016 Feb;173(4):766-77.

GB-83 (PAR2 inhibitor GB83)

生物&药学活性

物理化学性质&存储条件

参考文献

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GB-83 (PAR2 inhibitor GB83)

生物&药学活性

物理化学性质&存储条件

参考文献

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