Favezelimab | Anti-LAG3 mAb | Probechem Biochemicals

Chemical Structure : Favezelimab

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Favezelimab (MK-4280, Mavezelimab)

货号: PC-38822Not For Human Use, Lab Use Only.

规格	价格	库存	数量
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10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Mavezelimab (Favezelimab, MK-4280) is a humanized, immunoglobulin G4 (IgG4) monoclonal antibody (MAb) directed against the inhibitory receptor lymphocyte activation gene-3 protein (LAG3), with potential immune checkpoint inhibitory and antineoplastic activities.
Favezelimab (MK-4280) binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility complex (MHC) class II molecules expressed on tumor cells.
Favezelimab (MK-4280) activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction in tumor growth.
Isotype: IgG4-kappa.
Anti-[human LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)], humanized monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Bhagyashree Bhagwat, et al. J Immunol Methods. 2018 May;456:7-14.

Favezelimab (MK-4280, Mavezelimab)

生物&药学活性

物理化学性质&存储条件

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Favezelimab (MK-4280, Mavezelimab)

生物&药学活性

物理化学性质&存储条件

参考文献

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