Famitinib (SHR1020) |CAS:1044040-56-3 Probechem Biochemicals

Chemical Structure : Famitinib

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Famitinib (SHR1020, SHR-1020)

货号: PC-62597Not For Human Use, Lab Use Only.

Famitinib (SHR1020) is a structural analogue of sunitinib, novel and potent multi-targeted RTK inhibitor, including c-Kit, VEGFR2/3, PDGFRβ, FLT-1/3 receptor and c-RET.

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生物&药学活性

Famitinib (SHR1020) is a structural analogue of sunitinib, novel and potent multi-targeted RTK inhibitor, including c-Kit, VEGFR2/3, PDGFRβ, FLT-1/3 receptor and c-RET.
Famitinib (SHR1020) demonstrates the higher potency in tumour growth inhibition in human tumour xenograft models compared with sunitinib.

物理化学性质&存储条件

分子量	410.493
分子式	C23H27FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-5-(2-(diethylamino)ethyl)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-3-methyl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

参考文献

1. Xie C, et al. Br J Pharmacol. 2013 Apr;168(7):1687-706.

2. Zhang W, et al. Chin Med J (Engl). 2013 Nov;126(22):4277-81.

3. Zhou A, et al. Cancer Chemother Pharmacol. 2013 Nov;72(5):1043-53.

4. Ge S, et al. Oncol Lett. 2016 Sep;12(3):1763-1768.

Famitinib (SHR1020, SHR-1020)

生物&药学活性

物理化学性质&存储条件

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Famitinib (SHR1020, SHR-1020)

生物&药学活性

物理化学性质&存储条件

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