FTO inhibitor 8t

Chemical Structure : FTO inhibitor 8t

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货号: PC-23878Not For Human Use, Lab Use Only.

FTO inhibitor 8t is a novel specific small molecule inhibitor of RNA demethylase FTO with IC50 of 7.3 uM.

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生物&药学活性

FTO inhibitor 8t is a novel specific small molecule inhibitor of RNA demethylase FTO with IC50 of 7.3 uM.
FTO inhibitor 8t shows good selectivity against ALKBH5 but mild selectivity against ALKBH3.
FTO inhibitor 8t exhibits potent antiproliferative capacities against MOLM13, NB4, and THP-1 with IC50 values of 0.35, 0.59, and 0.70 μM, respectively, and remarkably induced NB4 cell apoptosis.
FTO inhibitor 8t also inhibited the FTO demethylation, enhanced the abundance of m6A, stabilized FTO protein folding, and regulated the oncogenic FTO signaling pathway.
FTO inhibitor 8t (30 mg/kg/d) significantly caused a tumor volume reduction and tumor weight loss with a tumor growth inhibition (TGI) value of 51% in NB4 xenograft model.

物理化学性质&存储条件

分子量	480.11
分子式	C18H12Br2N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N′-(3,5-Dibromo-2,4-dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide

参考文献

1. Liang X, et al. J Med Chem. 2025 Jan 16. doi: 10.1021/acs.jmedchem.4c02076.

FTO inhibitor 8t

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FTO inhibitor 8t

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