FR58P1a

Chemical Structure : FR58P1a

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货号: PC-35652Not For Human Use, Lab Use Only.

FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.

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生物&药学活性

FR58P1a is a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism, selectively inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
FR58P1a induces mitochondrial NADH oxidation, and Sirt1/AMPK-activation that in turn inhibits fibronectin-dependent migration of TNBC cells by decreasing β1-integrin at the cell surface.
FR58P1a activates AMPK in a Sirt1-dependent fashion, triggers metabolic adaptation but maintained the inhibitory effect of fibronectin-dependent migration in TNBC cells

物理化学性质&存储条件

分子量	477.395
分子式	C24H29BrO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(9,10-dihydroxy-4,8,8-trimethyl-5-oxo-1,4,5,8-tetrahydroanthracen-1-yl)methyl 6-bromohexanoate

参考文献

1. Urra FA, et al. Sci Rep. 2018 Sep 4;8(1):13190.

FR58P1a

生物&药学活性

物理化学性质&存储条件

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FR58P1a

生物&药学活性

物理化学性质&存储条件

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