FR-190997 | B2R agonist | Probechem Biochemicals

Chemical Structure : FR-190997

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FR-190997 (FR190997)

货号: PC-20273Not For Human Use, Lab Use Only.

FR-190997 (FR190997) is a potent, nonpeptide bradykinin (BK) B2 receptor agonist binding IC50 of 1.5 nM (displaced [3H]-BK binding to B2 receptors in guinea-pig ileum membranes).

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100 mg		Get quote

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生物&药学活性

FR-190997 (FR190997) is a potent, nonpeptide bradykinin (BK) B2 receptor agonist binding IC50 of 1.5 nM (displaced [3H]-BK binding to B2 receptors in guinea-pig ileum membranes).
FR-190997 displaces [3H]-BK binding to B2 receptors in human lung fibroblast IMR-90 cell with IC50 of 0.98 nM.
FR190997 induces concentration-dependent contraction of guinea-pig ilea with a pD2 of 7.9.
FR190997 induces concentration-dependent PI hydrolysis in IMR-90 cells with a pD2 of 8.4.
FR190997 expresses longer action than bradykinin in paw edema formation and hypotensive response in vivo.

物理化学性质&存储条件

分子量	698.60
分子式	C37H33Cl2N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(1E)-3-[[2-[[2,4-Dichloro-3-[[[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy]methyl]phenyl]methylamino]-2-oxoethyl]amino]-3-oxo-1-propen-1-yl]-N-methylbenzamide

参考文献

1. Asano M, et al. Br J Pharmacol. 1998 Jun;124(3):441-6.

2. Aramori I, et al. Mol Pharmacol. 1997 Jul;52(1):16-20.

3. Ueno A, et al. Immunopharmacology. 1999 Dec;45(1-3):89-93.

FR-190997 (FR190997)

生物&药学活性

物理化学性质&存储条件

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FR-190997 (FR190997)

生物&药学活性

物理化学性质&存储条件

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