FFN200 dihydrochloride | Fluorescent false neurotransmitter

Chemical Structure : FFN200 dihydrochloride

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FFN200 dihydrochloride (FFN-200 dihydrochloride)

货号: PC-20035Not For Human Use, Lab Use Only.

FFN200 dihydrochloride is a vesicular monoamine transporter 2 (VMAT2) substrate, and the first probe to selectively trace monoamine exocytosis in both neuronal cell culture and brain tissue.

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生物&药学活性

FFN200 dihydrochloride is a vesicular monoamine transporter 2 (VMAT2) substrate, and the first probe to selectively trace monoamine exocytosis in both neuronal cell culture and brain tissue.
FFN200 selectively labels striatal dopamine axons. exhibited a Km of 13.7 uM in VMAT2-transfected HEK cells was inhibited by tetrabenazine (TBZ).
The fluorescence excitation and emission maxima of FFN200 were determined to be 352 and 451 nm.
FFN200 accumulation in striatal axons depends on VMAT2.
FFN200 provides monitoring of individual bouton exocytosis.
FFN200 is the first fluorescent false neurotransmitter (FFN) to label dopaminergic neurons both in culture and in the acute brain slice.

物理化学性质&存储条件

分子量	277.15
分子式	C11H14Cl2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-amino-4-(2-aminoethyl)-2H-chromen-2-one dihydrochloride

参考文献

1. Daniela B Pereira, et al. Nat Neurosci. 2016 Apr;19(4):578-86.

FFN200 dihydrochloride (FFN-200 dihydrochloride)

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物理化学性质&存储条件

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FFN200 dihydrochloride (FFN-200 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

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