欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-抗体和重组蛋白-Biosimilar Antibody-Etevritamab
Etevritamab

Chemical Structure : Etevritamab

CAS No.: 2329692-74-0

加入收藏

Etevritamab (AMG 596)

货号: PC-38821Not For Human Use, Lab Use Only.

Etevritamab (AMG 596) is an EGFRvIII x CD3 bispecific T-cell engager (BiTE), AMG 596 is composed of two single-chain variable fragments that simultaneously bind to the tumor-specific antigen EGFR variant III (EGFRvIII) on GBM cells and to CD3 on T cells.

规格 价格 库存 数量
1 mg Get quote
5 mg Get quote
10 mg Get quote
25 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Etevritamab (AMG 596) is an EGFRvIII x CD3 bispecific T-cell engager (BiTE), AMG 596 is composed of two single-chain variable fragments that simultaneously bind to the tumor-specific antigen EGFR variant III (EGFRvIII) on GBM cells and to CD3 on T cells.
Etevritamab (AMG 596) activates T cells to proliferate and secrete cytotoxic substances, induces lysis of the bound tumor cell.
Etevritamab (AMG 596) is very potent and highly specific in vitro with EC50 values in the low picomolar range.
Etevritamab (AMG 596) treatment significantly increased the overall survival of mice bearing EGFRvIII-expressing orthotopic tumors, causes T-cell activation and T-cell-dependent lysis of GBM cells in vivo.
Isotype: Immunoglobulin scFv-scFv.
Anti-[human EGFR (epidermal growth factor receptor, receptor tyrosineprotein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)
variant III (EGFRvIII)] and anti-[human CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain, bispecific.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Sternjak A, et al. Mol Cancer Ther. 2021 May;20(5):925-933.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: