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首页-抗体和重组蛋白-Biosimilar Antibody-Erenumab
Erenumab

Chemical Structure : Erenumab

CAS No.: 1582205-90-0

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Erenumab (Anti-human CGRP mAb, human IgG2-Lambda; AMG-334)

货号: PC-Ab1070Not For Human Use, Lab Use Only.

Erenumab (AMG-334) is a fully human monoclonal antibody that selectively and potently binds to the canonical CGRP (calcitonin gene-related peptide receptor). Erenumab (AMG-334) competes with [(125)I]-CGRP binding to the human CGRP receptor, with a Ki of 0.02 nM. AMG 334 fully inhibited CGRP-stimulated cAMP production with an IC50 of 2.3 nM in cell-based functional assays (human CGRP receptor) and was 5000-fold more selective for the CGRP receptor than other human calcitonin family receptors, inc

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Erenumab (AMG-334) is a fully human monoclonal antibody that selectively and potently binds to the canonical CGRP (calcitonin gene-related peptide receptor). Erenumab (AMG-334) competes with [(125)I]-CGRP binding to the human CGRP receptor, with a Ki of 0.02 nM. AMG 334 fully inhibited CGRP-stimulated cAMP production with an IC50 of 2.3 nM in cell-based functional assays (human CGRP receptor) and was 5000-fold more selective for the CGRP receptor than other human calcitonin family receptors, including adrenomedullin, calcitonin, and amylin receptors. Erenumab blocks the activation of calcitonin gene-related peptide (CGRP), which can cause blood vessels to dilate and ellicit inflammation and migraine headache pain. Erenumab is used to prevent migraine headaches in adults.

物理化学性质&存储条件

分子量
分子式 Human IgG2-Lambda
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Erenumab; Aimovig; AMG-334; AMG334; anti-human calcitonin gene-related peptide receptor; CGRP receptor; Anti-human CGRP; 1582205-90-0

参考文献

1. 1, Shi L, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):223-31. 2, Tepper S, et al. Lancet Neurol. 2017 Jun;16(6):425-434. 3, Giamberardino MA, et al. J Pain Res. 2017 Dec 8;10:2751-2760. 4, Ashina M, et al. Neurology. 2017 Sep 19;89(12):1237-1243.

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