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首页-抗体和重组蛋白-Biosimilar Antibody-Eptinezumab
Eptinezumab

Chemical Structure : Eptinezumab

CAS No.: 1644539-04-7

Eptinezumab (Anti-human CGRP mAb, human IgG1 N297A-Kappa; ALD-403)

货号: PC-Ab1049Not For Human Use, Lab Use Only.

Eptinezumab (ALD-403) is a humanized monoclonal antibody to calcitonin gene like peptide (CGLP) which is used in the prevention of migraine headaches. Eptinezumab binds to alpha and beta forms of the CGRP ligand, preventing the ligand from binding to the receptor and blocking CGRP’s downstream effects, like pain transmission..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Eptinezumab (ALD-403) is a humanized monoclonal antibody to calcitonin gene like peptide (CGLP) which is used in the prevention of migraine headaches. Eptinezumab binds to alpha and beta forms of the CGRP ligand, preventing the ligand from binding to the receptor and blocking CGRP’s downstream effects, like pain transmission.

物理化学性质&存储条件

分子量
分子式 Human IgG1 N297A-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

Eptinezumab; Vyepti; Eptinezumab-jjmr; ALD-403; ALD403; 1644539-04-7; calcitonin gene–related peptide; anti-CGRP.

参考文献

1. 1, Villar-Martínez MD, et al. Pain Manag. 2021 Mar;11(2):113-121.  2, Dodick DW, et al. Headache. 2020 Nov;60(10):2220-2231. 3, Smith TR, et al. Clin Ther. 2020 Dec;42(12):2254-2265.e3. 4, Edvinsson L, et al. Nat Rev Neurol. 2018 Jun;14(6):338-350.

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