Eluvixtamab | CD33/CD3 BiTE | Probechem Biochemicals

Chemical Structure : Eluvixtamab

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Eluvixtamab (AMG 330)

货号: PC-38818Not For Human Use, Lab Use Only.

Eluvixtamab (AMG 330) is a CD33/CD3 bispecific T-cell engager (BiTE) antibody, shows potent CD33-dependent cytolytic activity in vitro and anti-AML activity in vivo.

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生物&药学活性

Eluvixtamab (AMG 330) is a CD33/CD3 bispecific T-cell engager (BiTE) antibody, shows potent CD33-dependent cytolytic activity in vitro and anti-AML activity in vivo.
AMG 330 binds with low nanomolar affinity to CD33 and CD3ε of both human and cynomolgus monkey origin.
AMG 330 was highly active against human AML cell lines and primary AML cells in a dose- and effector to target cell ratio-dependent manner.
AMG 330 specifically induced expression of CD69 and CD25 as well as release of IFN-γ, TNF, interleukin (IL)-2, IL-10, and IL-6 in AML cells.
AMG 330 (0.002 mg/kg, i.v.) significantly prolonged survival of immunodeficient mice adoptively transferred with human MOLM-13 AML cells and human T cells.
Isotype: Immunoglobulin scFv-scFv.
Anti-[human CD33 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67)] and anti-[human CD3E (CD3 epsilon)], monoclonal antibody single chain, bispecific.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Krupka C, et al. Leukemia. 2016 Feb;30(2):484-91.

2. Friedrich M, et al. Mol Cancer Ther. 2014 Jun;13(6):1549-57.

3. Krupka C, et al. Blood. 2014 Jan 16;123(3):356-65.

4. Laszlo GS, et al. Blood. 2014 Jan 23;123(4):554-61.

Eluvixtamab (AMG 330)

生物&药学活性

物理化学性质&存储条件

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Eluvixtamab (AMG 330)

生物&药学活性

物理化学性质&存储条件

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