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首页-抗体和重组蛋白-Biosimilar Antibody-Elotuzumab
Elotuzumab

Chemical Structure : Elotuzumab

CAS No.: 1223403-58-4

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Elotuzumab (Anti-human SLAMF7 mAb, human IgG1-Kappa; HuLuc63)

货号: PC-Ab1097Not For Human Use, Lab Use Only.

Elotuzumab (HuLuc63) is a humanized mAb that targets the cell surface adhesion molecule CS1, which is selectively expressed on more than 95% of plasma cells and has little to no expression on normal tissues. Elotuzumab binds to CS1 on MM cells and NK cells recognize the Fc region of antibody by CD16 and thus mediate ADCC (Antibody-dependent cell-mediated cytotoxicity) against MM cells. In addition, binding of Elotuzumab on CS1 on the NK cells activate natural cytotoxicity of NK cells. Activation

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elotuzumab (HuLuc63) is a humanized mAb that targets the cell surface adhesion molecule CS1, which is selectively expressed on more than 95% of plasma cells and has little to no expression on normal tissues. Elotuzumab binds to CS1 on MM cells and NK cells recognize the Fc region of antibody by CD16 and thus mediate ADCC (Antibody-dependent cell-mediated cytotoxicity) against MM cells. In addition, binding of Elotuzumab on CS1 on the NK cells activate natural cytotoxicity of NK cells. Activation of NK cells induce the secretion of IFN-γ and this. Elotuzumab has been approved in combination with lenalidomide and dexamethasone (ELd) for relapsed/refractory multiple myeloma (MM).

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Elotuzumab; Empliciti; HuLuc63; HuLuc 63; 1223403-58-4; Anti-human signaling lymphocytic activation molecule family 7; Anti human SLAMF7; Anti-human CD319; Anti-human CS1 (CD2 subset 1, CRACC); Anti-human CS1

参考文献

1. 1, Collins SM, et al. ancer Immunol Immunother. 2013 Dec;62(12):1841-9. 2, van Rhee F, et al. Mol Cancer Ther. 2009 Sep;8(9):2616-24.  3, Lonial S, et al. N Engl J Med. 2015 Aug 13;373(7):621-31.  4, Magen H, et al. Ther Adv Hematol. 2016 Aug;7(4):187-95. 5, Wang Y, et al. J Hematol Oncol. 2016 Jul 15;9(1):55.

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