Chemical Structure : Elotuzumab
CAS No.: 1223403-58-4
货号: PC-Ab1097Not For Human Use, Lab Use Only.
Elotuzumab (HuLuc63) is a humanized mAb that targets the cell surface adhesion molecule CS1, which is selectively expressed on more than 95% of plasma cells and has little to no expression on normal tissues. Elotuzumab binds to CS1 on MM cells and NK cells recognize the Fc region of antibody by CD16 and thus mediate ADCC (Antibody-dependent cell-mediated cytotoxicity) against MM cells. In addition, binding of Elotuzumab on CS1 on the NK cells activate natural cytotoxicity of NK cells. Activation
规格 | 价格 | 库存 | 数量 |
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Elotuzumab (HuLuc63) is a humanized mAb that targets the cell surface adhesion molecule CS1, which is selectively expressed on more than 95% of plasma cells and has little to no expression on normal tissues. Elotuzumab binds to CS1 on MM cells and NK cells recognize the Fc region of antibody by CD16 and thus mediate ADCC (Antibody-dependent cell-mediated cytotoxicity) against MM cells. In addition, binding of Elotuzumab on CS1 on the NK cells activate natural cytotoxicity of NK cells. Activation of NK cells induce the secretion of IFN-γ and this. Elotuzumab has been approved in combination with lenalidomide and dexamethasone (ELd) for relapsed/refractory multiple myeloma (MM).
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Elotuzumab; Empliciti; HuLuc63; HuLuc 63; 1223403-58-4; Anti-human signaling lymphocytic activation molecule family 7; Anti human SLAMF7; Anti-human CD319; Anti-human CS1 (CD2 subset 1, CRACC); Anti-human CS1 |
1. 1, Collins SM, et al. ancer Immunol Immunother. 2013 Dec;62(12):1841-9. 2, van Rhee F, et al. Mol Cancer Ther. 2009 Sep;8(9):2616-24. 3, Lonial S, et al. N Engl J Med. 2015 Aug 13;373(7):621-31. 4, Magen H, et al. Ther Adv Hematol. 2016 Aug;7(4):187-95. 5, Wang Y, et al. J Hematol Oncol. 2016 Jul 15;9(1):55.
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