Chemical Structure : Efonidipine hydrochloride
CAS No.:
111011-53-1
Efonidipine hydrochloride
(NZ-105 hydrochloride)
货号: PC-43071Not For Human Use, Lab Use Only.
Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation; increases coronary blood flow by blocking L & T-type calcium channels and attenuates myocardial ischaemia, lowers blood pressure in cerebral resistance vessels and prevents hypertension induced brain damage; increases glomerular filtration rate without increasing intra-glomerular pressure and filtration fraction.
物理化学性质&存储条件
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分子量
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668.1161
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分子式
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C34H39ClN3O7P
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20 °C 12 个月; 4°C 6 个月
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- 配置液
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-80 °C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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DMSO: 8.5 mg/mL
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Chemical Name/SMILES
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3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1)
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参考文献
1. Masuda Y, et al. Arch Int Pharmacodyn Ther. 1990 Mar-Apr;304:247-64.
2. Tamura T, et al. Naunyn Schmiedebergs Arch Pharmacol. 1991 Apr;343(4):405-10.
3. Shudo C, et al. Gen Pharmacol. 1994 Nov;25(7):1451-8.
4. Yamashita T, et al. Jpn J Pharmacol. 1991 Nov;57(3):337-48.
