Edasalonexent | NF-κB inhibitor | Probechem Biochemicals

Chemical Structure : Edasalonexent

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Edasalonexent (CAT-1004, CAT1004)

货号: PC-35289Not For Human Use, Lab Use Only.

Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF-κB, salicylic acid and docosahexaenoic acid (DHA).

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生物&药学活性

Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF-κB, salicylic acid and docosahexaenoic acid (DHA).
Edasalonexent (CAT-1004) significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever DMD model.
Edasalonexent (CAT-1004) is hydrolyzed by FAAH to release salicylic acid and DHA intracellularly and to suppress activated NF-κB.

物理化学性质&存储条件

分子量	490.688
分子式	C31H42N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl]amino]ethyl]-2-hydroxybenzamide

参考文献

1. Donovan JM, et al. J Clin Pharmacol. 2017 May;57(5):627-639.

2. Vu CB, et al. J Med Chem. 2016 Feb 11;59(3):1217-31.

Edasalonexent (CAT-1004, CAT1004)

生物&药学活性

物理化学性质&存储条件

参考文献

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Edasalonexent (CAT-1004, CAT1004)

生物&药学活性

物理化学性质&存储条件

参考文献

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