ERD03 | EXOSC3 inhibitor | Probechem Biochemicals

Chemical Structure : ERD03

CAS No.: 1377897-01-2

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ERD03 (EXOSC3-RNA disrupting compound 3)

货号: PC-35611Not For Human Use, Lab Use Only.

ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish.

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10 mg	￥5480	In stock
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生物&药学活性

ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish.
ERD03 recapitulates EXOSC3 knock-down effects on RNA transcriptomic profiles in zebrafish.
ERD03 induces an atrophy of the zebrafish cerebellum, a clinical feature of PCH1B, also induces modification of zebrafish RNA expression levels similar to that observed with a morpholino against EXOSC3.

物理化学性质&存储条件

分子量	339.44
分子式	C21H25NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinyl)[3-(3-hydroxy-3-methylbutyl)phenyl]methanone

参考文献

1. Francois-Moutal L, et al. ACS Chem Biol. 2018 Aug 24. doi: 10.1021/acschembio.8b00745.

ERD03 (EXOSC3-RNA disrupting compound 3)

生物&药学活性

物理化学性质&存储条件

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ERD03 (EXOSC3-RNA disrupting compound 3)

生物&药学活性

物理化学性质&存储条件

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