EPZ-011989 |CAS:1598383-40-4 Probechem Biochemicals

Chemical Structure : EPZ-011989

CAS No.: 1598383-40-4

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EPZ-011989 (EPZ011989)

货号: PC-45114Not For Human Use, Lab Use Only.

EPZ-011989 (EPZ011989) is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2880	In stock
100 mg		Get quote

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生物&药学活性

EPZ-011989 (EPZ011989) is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
EPZ-011989 equipotently inhibits mutant and wild-type EZH2, displays >15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTs.
EPZ-011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

物理化学性质&存储条件

分子量	605.8105
分子式	C35H51N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-

参考文献

1. Campbell JE, et al. ACS Med Chem Lett. 2015 Mar 4;6(5):491-5.

2. Gardner EE, et al. Cancer Cell. 2017 Feb 13;31(2):286-299.

EPZ-011989 (EPZ011989)

生物&药学活性

物理化学性质&存储条件

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EPZ-011989 (EPZ011989)

生物&药学活性

物理化学性质&存储条件

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