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首页-小分子抑制剂&激动剂-GPCR-Protease-activated Receptor (PAR)-ENMD-1068 hydrochloride
ENMD-1068 hydrochloride

Chemical Structure : ENMD-1068 hydrochloride

CAS No.: 2703451-51-6

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ENMD-1068 hydrochloride (ENMD1068)

货号: PC-61560Not For Human Use, Lab Use Only.

ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ENMD-1068 hydrochloride is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.
ENMD-1068 blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice, dose dependently attenuates joint inflammation.

物理化学性质&存储条件

分子量 319.87
分子式 C15H29N3O2.HCl
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-3-methylbutyryl-N4-6-aminohexanoyl-piperazine hydrochloride

参考文献

1. Kelso EB, et al. J Pharmacol Exp Ther. 2006 Mar;316(3):1017-24.

2. Kelso EB, et al. Arthritis Rheum. 2007 Mar;56(3):765-71.

3. Lohman RJ, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):256-65.

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