Diptoindonesin G |CAS:1190948-58-3 Probechem Biochemicals

Chemical Structure : Diptoindonesin G

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Diptoindonesin G (Dip G)

货号: PC-60204Not For Human Use, Lab Use Only.

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells.

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生物&药学活性

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.

物理化学性质&存储条件

分子量	360.321
分子式	C21H12O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,7,9-trihydroxy-1-(4-hydroxyphenyl)-6H-anthra[1,9-bc]furan-6-one

参考文献

1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21.

2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50.

3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765.

Diptoindonesin G (Dip G)

生物&药学活性

物理化学性质&存储条件

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Diptoindonesin G (Dip G)

生物&药学活性

物理化学性质&存储条件

参考文献

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