Enavogliflozin (GCC5694A) | SGLT-2 inhibitor | Probechem Biochemicals

Chemical Structure : DWP16001

CAS No.: 1415472-28-4

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DWP16001 (Enavogliflozin, GCC 5694A)

货号: PC-72663Not For Human Use, Lab Use Only.

DWP16001 (Enavogliflozin, GCC 5694A) is a potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor with IC50 of 0.46 nM (hSGLT2), > 700-fold selectivity against SGLT1.

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5 mg	￥3880	In stock
10 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

DWP16001 (Enavogliflozin, GCC 5694A) is a potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor with IC50 of 0.46 nM (hSGLT2), > 700-fold selectivity against SGLT1.
GCC5694A exhibited activity comparable to that of dapagliflozin.
Oral administration of GCC5694A (0.1–1 mg/kg) increased urinary glucose excretion in a dose-dependent manner.
In STZ-induced type 1 diabetic rats and type 2 diabetic db/db mice, repeated administration of GCC5694A (0.05–0.5 mg/kg) for 5 weeks significantly reduced the levels of hemoglobin A1c (HbA1c) and blood glucose.

物理化学性质&存储条件

分子量	446.924
分子式	C24H27ClO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-Glucitol, 1,5-anhydro-1-C-[7-chloro-6-[(4-cyclopropylphenyl)methyl]-2,3-dihydro-4-benzofuranyl]-, (1S)-

参考文献

1. Young Kyu Kong, et al. Bioorg Med Chem Lett. 2022 Jan 15;56:128466.

DWP16001 (Enavogliflozin, GCC 5694A)

生物&药学活性

物理化学性质&存储条件

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DWP16001 (Enavogliflozin, GCC 5694A)

生物&药学活性

物理化学性质&存储条件

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