BML-286 (Compound 3289-8625) | Dvl PDZ inhibitor | Probechem Biochemicals

Chemical Structure : Compound 3289-8625

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Compound 3289-8625 (BML-286)

货号: PC-49501Not For Human Use, Lab Use Only.

Compound 3289-8625 is a small molecule inhibitor of the PDZ domain of dishevelled (Dvl) with KD of 10.6 uM, competitively inhibits the Wnt signaling.

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生物&药学活性

BML-286 (Compound 3289-8625) is a small molecule inhibitor of the PDZ domain of dishevelled (Dvl) with KD of 10.6 uM, competitively inhibits the Wnt signaling.
Compound 3289-8625 (3 uM) inhibits Wnt signaling, effectively reduces luciferase activity by about 2-fold 293 cell line stably transfected with a luciferase reporter.
Compound 3289-8625 is cell-permeable and 3289-8625 (10 uM) blocks Wnt signaling in Xenopus, inhibits Wnt pathway responses in culture and in vivo.
Compound 3289-8625 suppresses cell proliferation and reduces β-catenin level in prostate cancer PC-3 cells, decreases the levels of β-catenin in both cytosolic fraction and membrane fraction.
Compound 3289-8625 sensitized A2780/Taxol cells to paclitaxel.

物理化学性质&存储条件

分子量	374.40
分子式	C22H18N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-(2-phenylacetamido)benzamido)benzoic acid

参考文献

1. David Grandy, et al. J Biol Chem. 2009 Jun 12;284(24):16256-16263.

Compound 3289-8625 (BML-286)

生物&药学活性

物理化学性质&存储条件

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Compound 3289-8625 (BML-286)

生物&药学活性

物理化学性质&存储条件

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