Compound 101 |CAS:865608-11-3 Probechem Biochemicals

Chemical Structure : Compound 101

CAS No.: 865608-11-3

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Compound 101 (GRK2 inhibitor 101;Takeda compound 101;Cmpd101)

货号: PC-60585Not For Human Use, Lab Use Only.

Compound 101 (GRK2 inhibitor 101, Takeda compound 101, Cmpd101) is a novel membrane-permeable, small-molecule inhibitor of GRK2 and GRK3 with IC50 of 18 nM and 5.4 nM, respectively.

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10 mg	￥1880	In stock
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生物&药学活性

Compound 101 (GRK2 inhibitor 101, Takeda compound 101, Cmpd101) is a novel membrane-permeable, small-molecule inhibitor of GRK2 and GRK3 with IC50 of 18 nM and 5.4 nM, respectively.
Compound 101 inhibits the desensitization of the G protein-activated inwardly-rectifying potassium current evoked by receptor-saturating concentrations of Met-Enk, DAMGO, endomorphin-2, and morphine in rat and mouse locus coeruleus neurons.
Compound 101 produces complete inhibition of DAMGO-induced MOPr phosphorylation at Ser(375), arrestin translocation, and MOPr internalization in HEK 293 cells.

物理化学性质&存储条件

分子量	466.468
分子式	C24H21F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(((4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)methyl)amino)-N-(2-(trifluoromethyl)benzyl)benzamide

参考文献

1. Lowe JD, et al. Mol Pharmacol. 2015 Aug;88(2):347-56.

Compound 101 (GRK2 inhibitor 101;Takeda compound 101;Cmpd101)

生物&药学活性

物理化学性质&存储条件

参考文献

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Compound 101 (GRK2 inhibitor 101;Takeda compound 101;Cmpd101)

生物&药学活性

物理化学性质&存储条件

参考文献

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