ChoKα inhibitor CK37 | ChoKα inhibitor | Probechem Biochemicals

Chemical Structure : ChoKα inhibitor CK37

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ChoKα inhibitor CK37 (CK37)

货号: PC-61516Not For Human Use, Lab Use Only.

ChoKα inhibitor CK37 is a potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site.

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生物&药学活性

ChoKα inhibitor CK37 is a potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site.
ChoKα inhibitor CK37 significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM cells to a slight increase in p62.
ChoKα inhibitor CK37 suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization, and reduces plasma membrane ruffling.
ChoKα inhibitor CK37 significantly decreases tumor growth in a lung tumor xenograft mouse model, suppresses tumor phosphocholine, and diminishes activating phosphorylations of ERK and AKT in vivo.

物理化学性质&存储条件

分子量	366.483
分子式	C20H22N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl] acetamide

参考文献

1. Clem BF, et al. Oncogene. 2011 Jul 28;30(30):3370-80.

2. Kim HS, et al. PLoS One. 2015 Oct 23;10(10):e0141110.

3. Wong MT, et al. J Virol. 2016 Sep 29;90(20):9075-95.

ChoKα inhibitor CK37 (CK37)

生物&药学活性

物理化学性质&存储条件

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ChoKα inhibitor CK37 (CK37)

生物&药学活性

物理化学性质&存储条件

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