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首页-抗体和重组蛋白-Biosimilar Antibody-Cetuximab
Cetuximab

Chemical Structure : Cetuximab

CAS No.: 205923-56-4

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Cetuximab (Anti-human EGFR mAb, human IgG1-Kappa; IMC-C225)

货号: PC-Ab1024Not For Human Use, Lab Use Only.

Cetuximab binds specifically to the extracellular domain of the human EGFR, and down-regulates constitutively activated EGFR vIII on the cell surface. It has also been investigated in advanced colorectal cancer, EGFR-expressing non-small cell lung cancer (NSCLC), and unresectable squamous cell skin cancer. Cetuximab is also indicated for K-Ras wild-type, EGFR-expressing, metastatic colorectal cancer as determined by an FDA-approved test in combination with FOLFIRI, a chemotherapy combination th

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5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cetuximab binds specifically to the extracellular domain of the human EGFR, and down-regulates constitutively activated EGFR vIII on the cell surface. It has also been investigated in advanced colorectal cancer, EGFR-expressing non-small cell lung cancer (NSCLC), and unresectable squamous cell skin cancer. Cetuximab is also indicated for K-Ras wild-type, EGFR-expressing, metastatic colorectal cancer as determined by an FDA-approved test in combination with FOLFIRI, a chemotherapy combination that includes leucovorin, fluorouracil, and irinotecan

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Cetuximab; ERBITUX; C225; IMC-C225; EGFR, ErbB-1, HER1; epidermal growth factor receptor; 205923-56-4

参考文献

1. 1, Cunningham D, et al. N Engl J Med. 2004 Jul 22;351(4):337-45. 2, Xiong HQ, et al. J Clin Oncol. 2004 Jul 1;22(13):2610-6.  3, Herbst RS, et al. Semin Oncol. 2002 Oct;29(5 Suppl 14):18-30. 4, Molli PR, et al. Clin Cancer Res. 2008 Oct 1;14(19):6161-70.

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