Chemical Structure : Cetuximab
CAS No.: 205923-56-4
货号: PC-Ab1024Not For Human Use, Lab Use Only.
Cetuximab binds specifically to the extracellular domain of the human EGFR, and down-regulates constitutively activated EGFR vIII on the cell surface. It has also been investigated in advanced colorectal cancer, EGFR-expressing non-small cell lung cancer (NSCLC), and unresectable squamous cell skin cancer. Cetuximab is also indicated for K-Ras wild-type, EGFR-expressing, metastatic colorectal cancer as determined by an FDA-approved test in combination with FOLFIRI, a chemotherapy combination th
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Cetuximab binds specifically to the extracellular domain of the human EGFR, and down-regulates constitutively activated EGFR vIII on the cell surface. It has also been investigated in advanced colorectal cancer, EGFR-expressing non-small cell lung cancer (NSCLC), and unresectable squamous cell skin cancer. Cetuximab is also indicated for K-Ras wild-type, EGFR-expressing, metastatic colorectal cancer as determined by an FDA-approved test in combination with FOLFIRI, a chemotherapy combination that includes leucovorin, fluorouracil, and irinotecan
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Cetuximab; ERBITUX; C225; IMC-C225; EGFR, ErbB-1, HER1; epidermal growth factor receptor; 205923-56-4 |
1. 1, Cunningham D, et al. N Engl J Med. 2004 Jul 22;351(4):337-45. 2, Xiong HQ, et al. J Clin Oncol. 2004 Jul 1;22(13):2610-6. 3, Herbst RS, et al. Semin Oncol. 2002 Oct;29(5 Suppl 14):18-30. 4, Molli PR, et al. Clin Cancer Res. 2008 Oct 1;14(19):6161-70.
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