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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-CRL1101
CRL1101

Chemical Structure : CRL1101

CAS No.: 328010-30-6

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CRL1101 (CRL-1101)

货号: PC-47045Not For Human Use, Lab Use Only.

CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.
    CRL1101 (15 uM) can sequester RelA in the cytoplasm in TNBC cell lines, MDA-MB-231 and MDA-MB-468.
    CRL1101 significantly inhibited cell proliferation with an inhibition constant of 15 uM in MDA-MB-231 and MDA-MB-468 cells.
    CRL1101 (25 mg/kg/day, i.p.) inhibits tumor growth in TNBC xenograft model.

    物理化学性质&存储条件

    分子量 332.346
    分子式 C13H17FN2O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-((4-fluoro-3-nitrophenyl)sulfonyl)propyl)morpholine

    参考文献

    1. Kanzaki H, et al. Breast Cancer (Dove Med Press). 2021 Jul 5;13:419-430.

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