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首页-小分子抑制剂&激动剂-Apoptosis-PKD-CID755673
CID755673

Chemical Structure : CID755673

CAS No.: 521937-07-5

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CID755673 (CID 755673;CID-755673)

货号: PC-42927Not For Human Use, Lab Use Only.

The first potent and selective cell-active pan-PKD inhibitor with IC50s of 182/280/227 nM for PKD1/2/3 respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CID755673 is the first potent and selective cell-active pan-PKD inhibitor with IC50s of 182/280/227 nM for PKD1/2/3 respectively.
CID755673 exhibits selectivity for PKD1 versus AKT, PLK1, CAK, CAMKIIα and three PKC isoforms.
CID755673 blockes phorbol ester-induced endogenous PKD1 activation in LNCaP cells and inhibits prostate cancer cell proliferation, cell migration and invasion.

物理化学性质&存储条件

分子量 217.2206
分子式 C12H11NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 40 mg/mL
Chemical Name/SMILES

1H-Benzofuro[2,3-c]azepin-1-one, 2,3,4,5-tetrahydro-7-hydroxy-

参考文献

1. Sharlow ER, et al. J Biol Chem. 2008 Nov 28;283(48):33516-26.

2. Torres-Marquez E, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):63-8.

3. Pilankatta R, et al. J Biol Chem. 2011 Mar 4;286(9):7389-96.

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