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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Transporter (GAT)-CI-966
CI-966

Chemical Structure : CI-966

CAS No.: 110283-79-9

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CI-966 (PD126141, CI 966)

货号: PC-62933Not For Human Use, Lab Use Only.

CI-966 (PD 126141) is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CI-966 (PD 126141) is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.
    CI-966 displays >200-fold selectivity over GAT-2 and GAT-3.
    CI-966 shows anticonvulsive and neuroprotective activity in vivo.

    物理化学性质&存储条件

    分子量 473.415
    分子式 C23H21F6NO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid

    参考文献

    1. Ebert U, et al. Can J Physiol Pharmacol. 1990 Sep;68(9):1194-9.

    2. Radulovic LL, et al. Pharm Res. 1993 Oct;10(10):1442-5.

    3. Phillis JW. Gen Pharmacol. 1995 Sep;26(5):1061-4.

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