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首页-抗体和重组蛋白-Biosimilar Antibody-CC-90002
CC-90002

Chemical Structure : CC-90002

CAS No.:

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CC-90002 (Anti-human CD47 mAb, human IgG4( S228P/L235E)-Kappa)

货号: PC-Ab1046Not For Human Use, Lab Use Only.

CC-90002 is a humanized IgG4-PE CD47 antibody that inhibits CD47-SIRPα interaction and enabled phagocytosis across a panel of cancer cell lines. CC-90002 is potentially differentiated from other CD47 immunotherapies by its lack of ability to induce hemagglutination of red blood cells or hemolysis in nonclinical studies. CD47 antibodies can synergize with the CD20 antibody rituximab to induce phagocytosis of NHL cells in vitroand to eliminate lymphoma in mouse models. CD47, also known as Integrin

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CC-90002 is a humanized IgG4-PE CD47 antibody that inhibits CD47-SIRPα interaction and enabled phagocytosis across a panel of cancer cell lines. CC-90002 is potentially differentiated from other CD47 immunotherapies by its lack of ability to induce hemagglutination of red blood cells or hemolysis in nonclinical studies. CD47 antibodies can synergize with the CD20 antibody rituximab to induce phagocytosis of NHL cells in vitroand to eliminate lymphoma in mouse models. CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a ubiquitous transmembrane protein that binds to SIRP family members on macrophages, neutrophils, and T cells.

物理化学性质&存储条件

分子量
分子式 Human IgG4( S228P/L235E)-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

CC-90002; CC90002; CC90002; Cluster of differentiation 47; integrin-associated protein; CD47-SIRPα interaction antibody

参考文献

1. 1, Narla RK, et al. Cancer Immunol Immunother. 2021 Jul 10. doi: 10.1007/s00262-021-03010-6. 2, Russ A, et al. Blood Rev. 2018 Nov;32(6):480-489. 3, Salvia Jain, et al. Blood. 2019 Oct 24; 134(17): 1430–1440.

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