CBP-93872 | G2 checkpoint inhibitor | ProbeChem Biochemicals

Chemical Structure : CBP-93872

加入收藏

CBP-93872 (CBP93872, CBP 93872)

货号: PC-70110Not For Human Use, Lab Use Only.

CBP-93872 is a potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint, inhibits NBS1-mediated ATR activation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CBP-93872 is a potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint, inhibits NBS1-mediated ATR activation.
CBP-93872 directly suppresses the growth of p53-mutated cancer cell lines with wild-type CDKN2A by eliciting G(1) arrest, but not CDKN2A-deleted and/or wild-type p53 lines.
CBP-93872 decreases phospho-cdc2 Y15 by inhibiting phosphorylation of Chk1.
CBP-93872 specifically inhibits DSB-mediated and Nbs1-dependent activation of ATR.

物理化学性质&存储条件

分子量	259.14
分子式	C10H15BrN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol

参考文献

1. Harada N, et al. Anticancer Drugs. 2011 Nov;22(10):986-94.

2. Hirokawa T, et al. Cancer Res. 2014 Jul 15;74(14):3880-9.

3. Iwata T, et al. PLoS One. 2017 May 30;12(5):e0178221.

CBP-93872 (CBP93872, CBP 93872)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CBP-93872 (CBP93872, CBP 93872)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.