Chemical Structure : Bevacizumab
CAS No.: 216974-75-3
货号: PC-Ab1010Not For Human Use, Lab Use Only.
A humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity, inhibits its interaction with VEGFR-1 and VEGFR-2. Bevacizumab inhibits the VEGF-induced proliferation of HUVEC with EC50 of 0.047 ug/ml.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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A humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity, inhibits its interaction with VEGFR-1 and VEGFR-2. Bevacizumab inhibits the VEGF-induced proliferation of HUVEC with EC50 of 0.047 ug/ml; induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Bevacizumab; Avastin; rhuMAb-VEGF; ascular Endothelial Growth Factor; VEGF-A; VEGFA; Vascular Permeability Factor; VPF Immunogen: Recombinant human VEGF. |
1. 1, L Manso, et al. Breast Cancer Res. 2009; 11(Suppl 1): P25. 2, David E. Piccioni,. et al. Neuro Oncol. 2014 Jun; 16(6): 815–822. 3, Mark R. et al. N Engl J Med. 2014 Feb 20; 370(8): 699–708. 4, Lambros Vamvakas, et al. BMC Cancer. 2014; 14: 277.
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