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首页-抗体和重组蛋白-Biosimilar Antibody-Belimumab
Belimumab

Chemical Structure : Belimumab

CAS No.: 356547-88-1

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Belimumab (Anti-human BAFF mAb, human IgG1 E239D,M241L-human lambda3 K83R)

货号: PC-Ab1086Not For Human Use, Lab Use Only.

Belimumab is a human IgG1λ monoclonal antibody that targets soluble human B lymphocyte stimulator proteins (BLyS, or BAFF and TNFSF13B). BLyS is unable to bind to receptors on B lymphocytes. The binding of BLyS to its receptor is essential for the survival of B lymphocytes. Consequently, belimumab reduces B-cell mediated immunity and the autoimmune response..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Belimumab is a human IgG1λ monoclonal antibody that targets soluble human B lymphocyte stimulator proteins (BLyS, or BAFF and TNFSF13B). BLyS is unable to bind to receptors on B lymphocytes. The binding of BLyS to its receptor is essential for the survival of B lymphocytes. Consequently, belimumab reduces B-cell mediated immunity and the autoimmune response.

物理化学性质&存储条件

分子量
分子式 Human IgG1 E239D, M241L-Human lambda3 K83R
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Belimumab; Benlysta; B-cell activating factor; BLyS ;TALL-1; THANK; anti-human B-Lymphocyte Stimulator TNFSF13B; anti-hBAFF; 356547-88-1

参考文献

1. 1, Navarra SV, et al. Lancet. 2011 Feb 26;377(9767):721-31. 2, Dooley MA, et al. Lupus. 2013 Jan;22(1):63-72. 3, Stohl W, et al. Arthritis Rheum. 2012 Jul;64(7):2328-37. 4, Vilas-Boas A, et al. MD Open. 2015 Mar 3;1(1):e000011.

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