Barecetamab | Anti-ErbB3 mAb | Probechem Biochemicals

Chemical Structure : Barecetamab

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Barecetamab (ISU104)

货号: PC-38855Not For Human Use, Lab Use Only.

规格	价格	库存	数量
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Barecetamab (ISU 104) is a highly potent, fully human anti-ErbB3 monoclonal antibody, binds potently and specifically to the NRG1 binding region of domain 3 of ErbB3, exhibits potent antitumorigenic activity.
Barecetamab (ISU 104) inhibited ligand binding, ligand-dependent heterodimerization and phosphorylation, and induced the internalization of ErbB3.
Barecetamab (ISU 104) inhibits downstream Akt phosphorylation and cell proliferation. Barecetamab (ISU 104) demonstrates anticancer efficacy in xenograft models of various cancers.
Isotype: IgG1-lambda
Anti-[human ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Mirim Hong, et al. Mol Cancer Ther. 2021 Jun;20(6):1142-1152.

Barecetamab (ISU104)

生物&药学活性

物理化学性质&存储条件

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Barecetamab (ISU104)

生物&药学活性

物理化学性质&存储条件

参考文献

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