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首页-小分子抑制剂&激动剂-GPCR-Angiotensin Receptor-Angiotensin 1-7
Angiotensin 1-7

Chemical Structure : Angiotensin 1-7

CAS No.: 51833-78-4

Angiotensin 1-7 (Talfirastide, Angiotensin (1-7), Ang-(1-7))

货号: PC-43019Not For Human Use, Lab Use Only.

Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Angiotensin (1-7) ((Ang-(1-7), Talfirastide) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM.
Angiotensin (1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide, abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2.
Angiotensin (1-7) evokes anti-arrhythmogenic effects in animal models, upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats.

物理化学性质&存储条件

分子量 899.0048
分子式 C41H62N12O11
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: ≥ 30.2 mg/mL

Chemical Name/SMILES

1-7-Angiotensin II, 5-L-isoleucine-

参考文献

1. Li P, et al. Hypertension. 1997 Jan;29(1 Pt 2):394-400.

2. Alzayadneh EM, et al. Cell Signal. 2014 Dec;26(12):3027-35.

3. Averill DB, et al. Circulation. 2003 Oct 28;108(17):2141-6.

4. Costa MA, et al. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1205-11.

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