AS 703569 |CAS:871357-89-0 Probechem Biochemicals

Chemical Structure : AS 703569

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AS 703569 (R763;Cenisertib)

货号: PC-62560Not For Human Use, Lab Use Only.

Cenisertib (AS 703569;R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).

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生物&药学活性

Cenisertib (AS 703569, R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).
Cenisertib (AS 703569, R763) demonstrates marked inhibition of tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia.

物理化学性质&存储条件

分子量	451.54
分子式	C24H30FN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2S,3R,4R)-3-((5-fluoro-2-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide

参考文献

1. McLaughlin J, et al. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113.

2. Illert AL, et al. PLoS One. 2014 Nov 26;9(11):e112318.

3. Peter B, et al. Leukemia. 2017 Nov 29. doi: 10.1038/leu.2017.338.

AS 703569 (R763;Cenisertib)

生物&药学活性

物理化学性质&存储条件

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AS 703569 (R763;Cenisertib)

生物&药学活性

物理化学性质&存储条件

参考文献

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