AQX 1125 |CAS:782487-28-9 Probechem Biochemicals

Chemical Structure : AQX 1125

CAS No.: 782487-28-9

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AQX 1125 (AQX-1125;AQX1125;Rosiptor)

货号: PC-50004Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg	￥7280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.
AQX 1125 (Rosiptor) inhibits the pAkt (S473) in MOLT-4 cells, and inhibits cytokine release in mixed splenocytes.
AQX 1125 (Rosiptor) significantly decreases β-hexosaminidase release in mouse BMMCs.
AQX 1125 (Rosiptor) inhibits chemotaxis in human mononuclear cells (EC50=0.26 uM).
AQX 1125 (Rosiptor) suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy.

物理化学性质&存储条件

分子量	321.505
分子式	C20H35NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping	Room temperature in continental US; may vary elsewhere
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexan-1-ol

参考文献

1. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1519-29.

2. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1506-18.

AQX 1125 (AQX-1125;AQX1125;Rosiptor)

生物&药学活性

物理化学性质&存储条件

参考文献

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AQX 1125 (AQX-1125;AQX1125;Rosiptor)

生物&药学活性

物理化学性质&存储条件

参考文献

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