APX3330 (E3330) | APE1 inhibitor | Probechem Biochemicals

Chemical Structure : APX3330

CAS No.: 136164-66-4

加入收藏

APX3330 (E3330, APX 3330, E 3330)

货号: PC-60634Not For Human Use, Lab Use Only.

APX3330 (E3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1) redox function (IC50=50 uM), but not APE1 DNA repair activity.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3680	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

APX3330 (E3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1) redox function (IC50=50 uM), but not APE1 DNA repair activity.
APX3330 (E3330) inhibits not only the growth but also the migratory abilities of pancreatic cancer cells in vitro, dramatically inhibits nuclear HIF-1α protein DNA-binding activity in PANC1 cells at >20 uM.
APX3330 (E3330) affects cytokine-mediated hemangioblast development in vitro.

物理化学性质&存储条件

分子量	378.46
分子式	C21H30O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid

参考文献

1. Zou GM, et al. Mol Cancer Ther. 2008 Jul;7(7):2012-21.

2. Nyland RL, et al. J Med Chem. 2010 Feb 11;53(3):1200-10.

3. Curtis CD, et al. Mol Endocrinol. 2009 Sep;23(9):1346-59.

4. Zou GM, et al. Blood. 2007 Mar 1;109(5):1917-22.

APX3330 (E3330, APX 3330, E 3330)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

APX3330 (E3330, APX 3330, E 3330)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.