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首页-抗体药物偶连体和PROTACs-PROTAC-AN2
AN2

Chemical Structure : AN2

CAS No.: 7758-73-8

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AN2 (HTT–LC3 linker AN2)

货号: PC-22413Not For Human Use, Lab Use Only.

AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
AN2 interacts with both mHTT and LC3B but not with wtHTT or irrelevant control proteins.
AN2 significantly lowered mHTT in cortices of HD mice.

物理化学性质&存储条件

分子量 254.24
分子式 C15H10O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,7-dihydroxy-4-phenylcoumarin

参考文献

1. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.

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