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首页-抗体药物偶连体和PROTACs-PROTAC-AN1
AN1

Chemical Structure : AN1

CAS No.: 486443-73-6

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AN1 (HTT–LC3 linker AN1)

货号: PC-22412Not For Human Use, Lab Use Only.

AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
AN1 interacts with both mHTT and LC3B but not with wtHTT or irrelevant control proteins.
AN1 significantly lowered mHTT in cortices of HD mice.

物理化学性质&存储条件

分子量 411.05
分子式 C15H9Br2NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one

参考文献

1. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.

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