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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-AMG-579
AMG-579

Chemical Structure : AMG-579

CAS No.: 1227067-61-9

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AMG-579 (AMG 579;AMG579)

货号: PC-60496Not For Human Use, Lab Use Only.

AMG-579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AMG-579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
AMG-579 displays high selectivity with IC50 > 30 uM against all other PDE isoforms.
AMG-579 demonstrates excellent target occupancy efficacy in PCP-LMA behavioral model.

物理化学性质&存储条件

分子量 441.491
分子式 C25H23N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone

参考文献

1. Hu E, et al. J Med Chem. 2014 Aug 14;57(15):6632-41.

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