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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-AL3810
AL3810

Chemical Structure : AL3810

CAS No.: 1058137-23-7

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AL3810 (AL-3810;AL 3810;E-3810;E3810;Lucitanib)

货号: PC-35892Not For Human Use, Lab Use Only.

AL3810 (AL-3810, E-3810, Lucitanib) is a potent, orally bioavailable, multiple tyrosine kinases inhibitor, potently inhibits VEGFR1/2/3 (IC50=7-25 nM) and FGFR1/2/3 (IC50=17.5-235 nM), also inhibits CSF1R with IC50 of 5 nM.

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10 mg ￥1580 In stock
25 mg ￥2580 In stock
100 mg ￥5980 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AL3810 (AL-3810, E-3810, Lucitanib) is a potent, orally bioavailable, multiple tyrosine kinases inhibitor, potently inhibits VEGFR1/2/3 (IC50=7-25 nM) and FGFR1/2/3 (IC50=17.5-235 nM), also inhibits CSF1R with IC50 of 5 nM.
AL3810 (AL-3810, E-3810, Lucitanib) shows some activity against PDGFR α and PDGFR β with 20 times lower potency, no significant activity against FGFR4 (IC50>1 uM).
AL3810 (AL-3810, E-3810, Lucitanib) causes dose-dependent inhibition of the ligand-dependent phosphorylation of VEGFR-2 and FGFR-1 in low nanomolar range in cellular assays, potently inhibits VEGF and bFGF-stimulated HUVEC proliferation with IC50 of 40-50 nM.
AL3810 (AL-3810, E-3810, Lucitanib) inhibits the growth of different human tumor xenografts in vivo.

物理化学性质&存储条件

分子量 443.503
分子式 C26H25N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(7-((1-aminocyclopropyl) methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide

参考文献

1. Zhou Y, et al. J Cell Mol Med. 2012 Oct;16(10):2321-30.

2. Bello E, et al. Cancer Res. 2011 Feb 15;71(4):1396-405. doi: 10.1158/0008-5472.CAN-10-2700.

3. Xie Q, et al. Acta Pharmacol Sin. 2017 Nov;38(11):1533-1542.

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